Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment
The precise relationship between epigenetic alterations and telomere dysfunction Water Features is still an extant question.Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters.Here, we uncovered that telomerase reverse transcr