TELOMERE DYSFUNCTION COOPERATES WITH EPIGENETIC ALTERATIONS TO IMPAIR MURINE EMBRYONIC STEM CELL FATE COMMITMENT

Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

The precise relationship between epigenetic alterations and telomere dysfunction Water Features is still an extant question.Previously, we showed that eroded telomeres lead to differentiation instability in murine embryonic stem cells (mESCs) via DNA hypomethylation at pluripotency-factor promoters.Here, we uncovered that telomerase reverse transcr

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Hypoxia endothelial cells-derived exosomes facilitate diabetic wound healing through improving endothelial cell function and promoting M2 macrophages polarization

It is imperative to develop and implement newer, more effective strategies to address refractory diabetic wounds.As of now, there is currently no optimal solution for these wounds.Hypoxic human umbilical vein endothelial cells (HUVECs)-derived exosomes have been postulated to promote diabetic wound healing, however, its effect and molecular mechani

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A Case of Free Flap Reconstruction after Endoscopic Debridemnt for Recalcitrant Nasopharyngeal Osteoradionecrosis Without Facial Incision

High-dose radiation therapy is the treatment of choice for nasopharyngeal cancer, and clinical outcomes have improved in recent decades.A certain proportion of patients, however, suffer from post-radiation nasopharyngeal necrosis (PRNN).Patients with PRNN complain of headache, foul odor, or symptoms of cranial nerve palsies.Clinically, intracranial

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